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Causes. a blockage in the lining of the appendix that results in infection is the likely cause of appendicitis. the bacteria multiply rapidly, causing the appendix to become inflamed, swollen and filled with pus.. Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. drug-induced liver injury is a cause of acute and chronic liver disease.. the liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.. Thomas farley, md, mph, is health commissioner for the city of philadelphia. dr. farley is a physician trained in pediatrics and epidemiology who has worked in a variety of roles in public health..
